While becoming less predominant in firearms designs, there are many great examples of pistols that include a thumb safety. Take, for instance, the venerable 1911. Of course, for those who choose to carry a handgun outfitted with this feature, there is an extra consideration. In particular, when in the draw sequence is it appropriate to disengage the safety? Rob Pincus does a pretty solid job of going over the basics of this topic in the above video. Perhaps as important, the firearms instructor and Gun Digest author also talks about when to reengage the safety. Obviously this is a key concern, given adrenaline of a situation that would demand a draw and the light trigger pull of a single-action pistol could easily add up to a negligent discharge.